Composite MRI scores improve correlation with EDSS in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Composite MRI scores improve correlation with EDSS in multiple sclerosis.
BACKGROUND Quantitative measures derived from magnetic resonance imaging (MRI) have been widely investigated as non-invasive biomarkers in multiple sclerosis (MS). However, the correlation of single measures with Expanded Disability Status Scale (EDSS) is poor, especially for studies with large population samples. OBJECTIVE To explore the correlation of MRI-derived measures with EDSS through ...
متن کاملInverse dependence between patient population and correlation of composite MRI scores with EDSS in Multiple Sclerosis
INTRODUCTION. In multiple sclerosis (MS), patient disability is assessed according to the qualitative, ordinal Expanded Disability Status Scale (EDSS). In order to monitor treatment efficacy and disease progression, quantitative MRI metrics are sought that will correlate with EDSS [1]. In the relapsing-remitting MS (RRMS) literature, r-values for correlation with EDSS of various metrics have ra...
متن کاملPupillary disturbances in multiple sclerosis: correlation with MRI findings.
UNLABELLED Autonomic nervous system disturbances such as pupillary abnormalities have rarely been evaluated in multiple sclerosis (MS). However, pupillary impairment is not uncommon in MS and its origin is still unclear. The aim of this study was to investigate pupillary disturbances in MS and to try to correlate pupillary defects with spinal cord and brainstem magnetic resonance imaging (MRI) ...
متن کاملCorrelation of MRI findings and cognitive function in multiple sclerosis patients using montreal cognitive assessment test
Background: Magnetic resonance imaging (MRI) has improved the diagnosis and management of patients with multiple sclerosis (MS). Montreal Cognitive Assessment (MoCA) is a brief, sensitive test that has been recommended by National Institute of Neurological Diseases and Stroke and Canadian Stroke Network (NINDS-CSN) as a reliable tool to detect mild cognitive impairments. This study aimed to eva...
متن کاملSystematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis
BACKGROUND There are a number of instruments that describe severity and progression of multiple sclerosis and they are increasingly used as endpoints to assess the effectiveness of therapeutic interventions. We examined to what extent the psychometric properties of two accepted instruments--EDSS and MSFC--meet methodological standards and the value they have in clinical trials. METHODS We con...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Multiple Sclerosis Journal
سال: 2010
ISSN: 1352-4585,1477-0970
DOI: 10.1177/1352458510374892